The comedy duo of Bud Abbott and Lou Costello appeared in dozens of films during the 1940s and 1950s, four of which take place in the Crossover Universe.
Crossover chronology
| Story | Publication | Crossovers |
| 1883 - Abbott and Costello Meet Dr. Jekyll and Mr. Hyde | 1954 film | Dr. Jekyll and Mr. Hyde |
| 1948 - Abbott and Costello Meet Frankenstein | 1948 film | Frankenstein The Wolf Man Dracula The Invisible Man |
| 1949 - Abbott and Costello Meet the Invisible Man | 1951 film | The Invisible Man |
| 1954 - Abbott and Costello Meet the Mummy | 1955 film | The Mummy |
| 1980 - The Black Cat Always Lands on Her Feet | Amazing Spider-Man #204-205, May-June 1980 | see Spider-Man |
| Bud and Lou appear as security guards at the Hendricks Museum. | ||
| 1998 - Return of the Wolf Man | 1998 novel | see The Wolf Man |
| The events of the aforementioned films as well as Mexican Hayride, Africa Screams, and Abbott and Costello in the Foreign Legion are alluded to. | ||